The Center is involved in studying the foreign policy of the United States as well as Ukraine-U.S. relations, American studies, in general. Accent in research (and teaching) has been given to the study of historic evolution, conceptual background and present day of U.S. foreign policy. This has reflected itself in a wide set of activities, ranging from teaching the course on U.S. foreign policy (by V. Dubovyk and I. Koval since 1999) to holding round-tables (including the one on U.S.-Ukraine relations in 2003, which was funded by the Bureau of Educational and Cultural Affairs, Department of State) to hosting visiting fellows.

The Center has hosted a U.S. Peace Corps Volunteer Anita Petrosky, CEP Visiting Scholar Albert Ringelstein, Fulbright Senior Scholar David Churchman. Director of the Center V. Dubovyk took part in various activities of the American Studies Association in Ukraine (ASAU). He is also often joined by other colleagues in giving lectures and convening round-tables, related to the issues in domestic and foreign policies of the U.S., including numerous of those under the framework of the Odessa Seminar on Theory, History and Historiography of International Relations (THHIR).

The Center has offered its premises for the regional office of IREX (International Research and Exchanges Board) in 1999 - 2005. The Center’s Senior Research Fellow Denys Kuzmin was its field representative. The Center has done a number of research and teaching development workshops, trainings and alumni events with IREX.